Journal of Biology and Medicine: Open Access
Cardiotoxic Effects of Car Paint Fumes Exposure on Cardiac Tissues of Male Wistar Rats
Saka WA, Kehinde BD, Akintola AO, Akwu BP, Ibikunle GJ, Owolabi GO, Adeshina OS, and Folorunso KP
Abstract
Background: The majority of the people are exposed to hazardous paint fumes at some point in their lifetime either through their occupation, home, car refurbishing or through any contact. This current study examined the impact of automobile paint fumes on male abino wistar rats. Method: Forty matured male Wistar rats weighing 180-300g were used for the study. The rats were divided into five group A-E of eight rats per group. Group A served as control while Group B-E served as the experimental animals. Group A received only feed and clean water for 14 days. Group B-D were exposed to 40ml of Clear coat, Thinner and Hardener fume each via inhalation in addition to feed and water for 14 days. Group E: CTH (Clear + thinner + hardener)-exposed groups were exposed to 13.5ml of Clear coat + 13.5ml of thinner and 1 3.3 ml of Hardener fume via inhalation in addition to feeding and water for the 14 days. At the end of two-weeks experiment, animals were sacrificed by cervical dislocation. Blood and heart tissues were harvested and used for biochemical and histopathological study. Result: Exposure to car paint fumes caused cardiac damage evidenced by significant alteration in cardiac activity (Troponin-I, CK-MB, AST, LDH), lipid profile (HDL, LDL, CHOL, TAG) and antioxidant status (SOD, CAT, GSH, MDA, NO, XO) as compared to control rats. Conclusion: The results of these findings thus inferred that exposure to paint fume may be toxic to the heart.
Keywords: Paint fumes, Thinner, Hardener, Clear coat, Lipid profile.
Journal Information
- Journal Name: Journal of Biology and Medicine: Open Access
- Journal Abbreviation: J Bio Med Open Access
- Journal Code: JBMOA
- Format of Publication: Online
- Frequency of Publication: Two Issue a Year
- Language: English
- Starting Year: 2020
- Subject: Biology, Medicine, Medical Sciences
- Review Process: Single-Blind Peer-Review by Referees
- Time to 1st Decision: 1 to 4 weeks from date of submission
- Time to Acceptance: 3 to 6 weeks, depending upon the required revision cycles
- Time to Publication: 1 to 2 weeks from date of final submission
- Editor-in-Chief: CHEE KONG YAP
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